Figure 6.

(A) Effect of treatment with temsirolimus on the in vivo growth of ACHN sublines. Twenty nude mice were subcutaneously given 5 × 10⁶ cells of each ACHN subline, then randomly selected for treatment with either 10 mg kg⁻¹ of temsirolimus or vehicle three times per week for 4 weeks, and the subcutaneous tumour volume was measured using calipers. Bars, s.d. ** and *, differ from ACHN/P (P<0.01 and P<0.05, respectively). (B) Effect of treatment with KU0063794 on the in vivo cell growth of ACHN sublines. Ten nude mice were subcutaneously given 5 × 10⁶ cells of each ACHN subline, then treated with 8 mg kg⁻¹ of KU0063794 twice per week for 4 weeks, and the subcutaneous tumour volume was measured using calipers. Bars, s.d.