Figure 1.

Observed vs. predicted acetaminophen plasma concentration profiles in adults included in model development following i.v. (a,b,c) and oral (d,e,f) doses of acetaminophen. Symbols represent individual or mean observed data digitized from different literature. The solid, dashed, and dotted lines represent the predicted mean and 5% or 95% confidence interval of the current physiologically based current pharmacokinetic model at respective doses in adults. Literature sources for (d,e,f) oral administration data are presented in Supplementary Material 2 online. i.v., intravenous.