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Simulated 24-h urinary recovery profiles of acetaminophen (APAP) metabolites in different pediatric age groups with the developed physiologically based pharmacokinetic (PBPK) model. Solid, broken, and dashed lines represent the changes of proportion of APAP-glutathione (APAP-GSH) (reflecting bioactivation), APAP-sulphate (APAP-S), and APAP-glucuronide (APAP-G), respectively, in the urine as age increases from newborns (0 years) to adults (18–20 years).
