Table 4.
Kidney Cancer Odds Ratios by Various Metrics of Arsenic Intake and Histological Subtype, Northern Chile, 2007–2010
| Exposure Metric | No. of Controls | Renal Pelvis and Ureter Cancers (TCCs) |
Renal Cell Cancers |
Other/Unclassified Cancers |
All Kidney Cancers |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Cases | OR | 95% CI | No. of Cases | OR | 95% CI | No. of Cases | OR | 95% CI | No. of Cases | OR | 95% CI | ||
| Highest 5-year daily average of arsenic intake, µg/day | |||||||||||||
| <400 | 405 | 5 | 1.00 | 53 | 1.00 | 13 | 1.00 | 71 | 1.00 | ||||
| 400–1,000 | 141 | 8 | 5.71 | 1.65, 19.82 | 10 | 0.52 | 0.25, 1.07 | 7 | 1.52 | 0.57, 4.01 | 25 | 1.00 | 0.60, 1.67 |
| >1,000 | 94 | 11 | 11.09 | 3.60, 34.16 | 13 | 1.24 | 0.64, 2.43 | 2 | 0.59 | 0.13, 2.72 | 26 | 1.76 | 1.05, 2.95 |
| Ptrend | <0.001 | 0.72 | 0.69 | 0.11 | |||||||||
| Highest daily arsenic intake before 1971, µg/day | |||||||||||||
| <400 | 415 | 7 | 1.00 | 53 | 1.00 | 14 | 1.00 | 74 | 1.00 | ||||
| 400–1,000 | 122 | 6 | 3.36 | 1.02, 11.10 | 10 | 0.59 | 0.29, 1.23 | 6 | 1.47 | 0.53, 4.05 | 22 | 1.02 | 0.60, 1.75 |
| >1,000 | 103 | 11 | 7.13 | 2.61, 19.44 | 13 | 1.06 | 0.55, 2.06 | 2 | 0.53 | 0.12, 2.43 | 26 | 1.53 | 0.92, 2.55 |
| Ptrend | <0.001 | 0.68 | 0.57 | 0.18 | |||||||||
| Cumulative arsenic exposure, mg | |||||||||||||
| <10 | 418 | 7 | 1.00 | 58 | 1.00 | 15 | 1.00 | 80 | 1.00 | ||||
| 10–25 | 168 | 12 | 5.49 | 2.02, 14.88 | 11 | 0.52 | 0.26, 1.03 | 5 | 0.77 | 0.27, 2.22 | 28 | 0.96 | 0.59, 1.55 |
| >25 | 54 | 5 | 10.35 | 2.57, 41.64 | 7 | 1.25 | 0.53, 2.96 | 2 | 0.91 | 0.20, 4.21 | 14 | 1.69 | 0.87, 3.26 |
| Ptrend | 0.008 | 0.49 | 0.89 | 0.06 | |||||||||
Abbreviations: CI, confidence interval; OR, odds ratio; TCC, transitional cell carcinoma.