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. 2013 Oct 30;9:2265–2319. doi: 10.3762/bjoc.9.265

Table 1.

Chemical structures of the heterocyclic compounds discussed in this review.

Name Label Structure Heterocycle Scheme

Nicotinic acid 1.12 graphic file with name Beilstein_J_Org_Chem-09-2265-i001.jpg pyridine 2,3
Niacin 1.18 graphic file with name Beilstein_J_Org_Chem-09-2265-i002.jpg pyridine 3
Clarinex 1.22 graphic file with name Beilstein_J_Org_Chem-09-2265-i003.jpg pyridine 5
Rabeprazole 1.33 graphic file with name Beilstein_J_Org_Chem-09-2265-i004.jpg pyridine 6,7
Pantoprazole 1.34 graphic file with name Beilstein_J_Org_Chem-09-2265-i005.jpg pyridine 6,7
Lansoprazole 1.35 graphic file with name Beilstein_J_Org_Chem-09-2265-i006.jpg pyridine 6,7
Rosiglitazone 1.40 graphic file with name Beilstein_J_Org_Chem-09-2265-i007.jpg pyridine 8,11
Pioglitazone 1.41 graphic file with name Beilstein_J_Org_Chem-09-2265-i008.jpg pyridine 12–16
Etoricoxib 1.90 graphic file with name Beilstein_J_Org_Chem-09-2265-i009.jpg pyridine 17,18
Moxifloxacin 1.102 graphic file with name Beilstein_J_Org_Chem-09-2265-i010.jpg quinolone 19,20
Levofloxacin 1.103 graphic file with name Beilstein_J_Org_Chem-09-2265-i011.jpg quinolone 21,22
Nifedipine 2.1 graphic file with name Beilstein_J_Org_Chem-09-2265-i012.jpg dihydropyridine 23
Amlodipine 2.2 graphic file with name Beilstein_J_Org_Chem-09-2265-i013.jpg dihydropyridine 24,25
Clevidipine 2.3 graphic file with name Beilstein_J_Org_Chem-09-2265-i014.jpg dihydropyridine 26
Tiagabine 2.36 graphic file with name Beilstein_J_Org_Chem-09-2265-i015.jpg piperidine 27
Solifenacin 2.57 graphic file with name Beilstein_J_Org_Chem-09-2265-i016.jpg piperidine 28
Carmegliptine 2.70 graphic file with name Beilstein_J_Org_Chem-09-2265-i017.jpg piperidine 30
Lamivudine 3.1 graphic file with name Beilstein_J_Org_Chem-09-2265-i018.jpg pyrimidine 33
Raltegravir 3.18 graphic file with name Beilstein_J_Org_Chem-09-2265-i019.jpg pyrimidine 34
Imatinib 3.36 graphic file with name Beilstein_J_Org_Chem-09-2265-i020.jpg pyrimidine 37,38
Erlotinib 3.37 graphic file with name Beilstein_J_Org_Chem-09-2265-i021.jpg pyrimidine 39,40
Lapatinib 3.38 graphic file with name Beilstein_J_Org_Chem-09-2265-i022.jpg pyrimidine 41
Rosuvastatin 3.80 graphic file with name Beilstein_J_Org_Chem-09-2265-i023.jpg pyrimidine 42,43
Varenicline 4.1 graphic file with name Beilstein_J_Org_Chem-09-2265-i024.jpg pyrazine 44
Eszopiclone 4.26 graphic file with name Beilstein_J_Org_Chem-09-2265-i025.jpg pyrazine 45
Brimonidine 4.22 graphic file with name Beilstein_J_Org_Chem-09-2265-i026.jpg pyrazine 45
Bortezomib 4.27 graphic file with name Beilstein_J_Org_Chem-09-2265-i027.jpg pyrazine 46
Aplaviroc 4.37 graphic file with name Beilstein_J_Org_Chem-09-2265-i028.jpg piperazine 47
Azelastine 5.1 graphic file with name Beilstein_J_Org_Chem-09-2265-i029.jpg pyridazine 48
Cilazapril 5.12 graphic file with name Beilstein_J_Org_Chem-09-2265-i030.jpg perhydro-pyridazine 49
Lamotrigine 6.1 graphic file with name Beilstein_J_Org_Chem-09-2265-i031.jpg 1,2,4-triazine 50,51
Imiquimod 6.11 graphic file with name Beilstein_J_Org_Chem-09-2265-i032.jpg imidazoquinoline 52–54
Abacavir 6.37 graphic file with name Beilstein_J_Org_Chem-09-2265-i033.jpg purine 55
Ocinaplon 6.48 graphic file with name Beilstein_J_Org_Chem-09-2265-i034.jpg pyrazolo-pyrimidine 56
Zaleplon 6.46 graphic file with name Beilstein_J_Org_Chem-09-2265-i035.jpg pyrazolo-pyrimidine 57
Indiplon 6.54 graphic file with name Beilstein_J_Org_Chem-09-2265-i036.jpg pyrazolo-pyrimidine 57
Sildenafil 6.61 graphic file with name Beilstein_J_Org_Chem-09-2265-i037.jpg pyrazolo-pyrimidone 58–61
Vardenafil 6.87 graphic file with name Beilstein_J_Org_Chem-09-2265-i038.jpg imidazotriazinone 62–65
Temozolomide 6.105 graphic file with name Beilstein_J_Org_Chem-09-2265-i039.jpg imidazo-tetrazinone 66–68