Table 4.
Adverse Drug Events
| Adverse Drug Events | Control (n=42)a | Aprepitant (n=46)b | p Value |
|---|---|---|---|
| Malaise (%) | 42 (100) | 43 (94.1) | 0.243 |
| Diarrhea (%) | 40 (87.5) | 37 (80.0) | 0.052 |
| Headache (%) | 22 (46.9) | 26 (55.9) | 0.831 |
| Skin rash and flushing (%) | 17 (37.5) | 16 (35.3) | 0.662 |
| Insomnia (%) | 20 (43.8) | 14 (29.4) | 0.126 |
| Constipation (%) | 1 (3.1) | 7 (14.7) | 0.060 |
| Abdominal pain (%) | 12 (25.0) | 4 (8.8) | 0.025 |
| Hiccups (%) | 7 (15.6) | 4 (8.8) | 0.339 |
| Tremors (%) | 3 (6.3) | 3 (5.9) | 1.000 |
| Hypersensitivity (%) | 0 (0) | 3 (5.9) | 0.243 |
| Dizziness (%) | 1 (3.1) | 1 (2.9) | 1.000 |
| Dysuria (%) | 0 (0) | 1 (2.9) | 1.000 |
| Back pain (%) | 4 (9.4) | 0 (0) | 0.048 |
| Muscle pain (%) | 3 (6.3) | 0 (0) | 0.105 |
a
Patients in the control group received granisetron alone as an antiemetic.
b
Patients in the aprepitant group received aprepitant and granisetron as antiemetics.