Table 5.
Blood Concentrations of Calcineurin Inhibitors
| Control (n=42)a | Aprepitant (n=46)b | p Value | |
|---|---|---|---|
| Cyclosporine A | |||
| Day 0 | 157.7 ± 57.4 | 164.1 ± 79.7 | 0.789 |
| Day 1 | 170.9 ± 60.7 | 157.1 ± 33.7 | 0.432 |
| Day 2 | 178.4 ± 46.2 | 198.2 ± 45.8 | 0.549 |
| Tacrolimus | |||
| Day 0 | 12.8 ± 5.3 | 13.3 ± 5.6 | 0.786 |
| Day 1 | 13.1 ± 3.6 | 13.8 ± 6.4 | 0.673 |
| Day 2 | 14.0 ± 3.4 | 14.3 ± 4.7 | 0.799 |
Cyclosporine A and tacrolimus blood concentrations were compared on the day of hematopoietic stem cell transplantation (day 0) and the following 2 days. Calcineurin inhibitor concentrations were expressed as the mean ± SD.
a
Patients in the control group received granisetron alone as an antiemetic.
b
Patients in the aprepitant group received aprepitant and granisetron as antiemetics.