Table 1.
Patient Characteristics | Preoperative CA19-9 (n = 176)
|
Pre- and Postoperative CA19-9 (n = 111)
|
||
---|---|---|---|---|
No. | % | No. | % | |
Preoperative factors | ||||
Age at operation, years | ||||
Minimum | 33.8 | 33.8 | ||
Median | 68.7 | 66.8 | ||
Mean | 66.9 | 65.5 | ||
Maximum | 91.0 | 91.0 | ||
Female | 99 | 56 | 55 | 50 |
Abdominal pain | 109 | 62 | 71 | 64 |
Weight loss | 105 | 60 | 68 | 61 |
Diabetes | 31 | 18 | 16 | 14 |
Smoker | 90 | 55 | 61 | 57 |
Jaundice | 105 | 60 | 62 | 56 |
ERCP | 137 | 78 | 83 | 75 |
Stent | 103 | 59 | 61 | 55 |
Tumor biopsy | ||||
Not performed | 112 | 64 | 69 | 62 |
Percutaneous | 13 | 7 | 9 | 8 |
EUS guided | 43 | 24 | 27 | 24 |
ERCP guided | 8 | 5 | 6 | 5 |
| ||||
Operative factors | ||||
Tumor location | ||||
Head | 136 | 77 | 84 | 76 |
Body | 18 | 10 | 11 | 10 |
Tail | 22 | 13 | 16 | 14 |
Type of resection | ||||
Whipple | 137 | 78 | 86 | 77 |
Distal | 32 | 18 | 21 | 19 |
Total | 7 | 4 | 4 | 4 |
Portal vein resected | 7 | 4 | 5 | 5 |
Pylorus preserving | 14 | 8 | 12 | 11 |
Splenectomy | 23 | 13 | 16 | 14 |
Blood transfusion | 51 | 29 | 32 | 29 |
| ||||
Pathologic factors | ||||
Margin of resection | ||||
Negative, overall | 137 | 78 | 88 | 79 |
Positive | 39 | 22 | 23 | 21 |
Cytology | ||||
Positive | 5 | 3 | 4 | 4 |
Negative | 42 | 24 | 33 | 30 |
Not performed | 129 | 73 | 74 | 67 |
Differentiation | ||||
Not assessed | 8 | 5 | 3 | 3 |
Well differentiated | 10 | 6 | 7 | 6 |
Moderately differentiated | 97 | 55 | 63 | 57 |
Poorly differentiated | 60 | 35 | 38 | 34 |
Tumor stage | ||||
T1 | 19 | 11 | 11 | 10 |
T2 | 29 | 16 | 16 | 14 |
T3 | 128 | 73 | 84 | 76 |
Node stage | ||||
N0 | 77 | 44 | 45 | 41 |
N1 | 99 | 56 | 66 | 59 |
Perineural invasion | 127 | 72 | 81 | 73 |
Vascular invasion | 57 | 32 | 37 | 33 |
Lymphatic Invasion | 77 | 44 | 53 | 48 |
AJCC stage | 32 | 18 | 18 | 16 |
IIa | 44 | 25 | 26 | 23 |
IIb | 98 | 56 | 65 | 59 |
IV | 2 | 1 | 2 | 2 |
| ||||
Adjuvant therapy | ||||
Preoperative chemotherapy | 10 | 6 | 7 | 6 |
Postoperative chemotherapy | 112 | 64 | 87 | 78 |
Preoperative XRT | 46 | 26 | 35 | 32 |
Intraopertive XRT | 18 | 10 | 14 | 13 |
Postoperative XRT | 97 | 55 | 72 | 65 |
Abbreviations: ERCP, endoscopic retrograde cholangiopancreatography; EUS, endoscopic ultrasound; AJCC, American Joint Committee on Cancer; XRT, radiation therapy.