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Synthesis of simple 3-carboxamide tetramic acids. Reaction conditions: (a) triethylamine (2.0 equiv), 1-bromohexane (0.5 equiv), EtOH, reflux; (b) monoethyl malonate (1.1 equiv), DCC (1.1 equiv), CH2Cl2, rt; (c) NaOMe (1.1 equiv), benzene, EtOH, reflux; (d) RNH2 (1.0 equiv), toluene, reflux.
