Table 4.

Antibiotic activity of tetramic acid 2b.^a

Strains	Phenotype	MIC (µg/mL)
		2b	Moxi	Amox	Ery	Vanco	Caz
S. pneumoniae Pn7	EryR	2	0.125	4	16	0.25	−c
S. pneumoniae Pn10	PenR, EryR	2	0.125	4	>32	0.5	−c
S. pneumoniae Pn11	PenR	2	0.125	4	<0.03	0.25	−c
S. pneumoniae Pn19	EryR	2	0.06	0.06	>32	0.5	−c
S. pneumoniae Pn21	EryR	2	0.06	0.125	4	0.25	−c
S. pneumoniae Pn31	EryR	0.13	<0.03	<0.03	16	0.5	−c
S. aureus Sa5	ermR PK2b	1	≤0.03	−c	−c	−c	32
S. aureus Sa18	FQR	1	32	−c	−c	−c	16
S. aureus Sa40	mecAb	1	≤0.03	−c	−c	−c	32

^aAbbreviation: EryR; erythromycin resistant, PenR; penicillin resistant, FQR; fluoroquinolone resistant, Moxi; moxifloxacin, Amox; amoxicillin, Ery; erythromycin, Caz; ceftazidime. ^bMethicillin-resistant strain. ^cNot determined.