Table 2. Risk of developing subsequent internal organ involvement in early diffuse systemic sclerosis patients presenting with tendon friction rubs at the first visit.
| Odds Ratio |
95% Confidence Interval |
p-value | |
|---|---|---|---|
|
| |||
| Renal crisis | 3.05 | 1.59 – 5.87 | 0 .0008 |
| Cardiac | 3.71 | 1.69-8.12 | < .0001 |
| Pulmonary * | 1.84 | 1.05 – 3.22 | 0.03 |
| Gastrointestinal | 4.57 | 2.00 – 10.36 | 0.0003 |
| Skeletal muscle | 4.00 | 0.85 – 18.84 | 0.08 |
| Pulmonary hypertension | 1.40 | 0.71 - 2.78 | 0.33 |
| Severe peripheral vascular † | 1.10 | 0.47 – 2.59 | 0.83 |
| Joint contractures | 2.67 | 0.85 – 18.84 | 0.15 |
|
| |||
| ADJUSTED FOR SIGNIFICANT BASELINE DIFFERENCES ‡ | |||
| Renal crisis | 2.66 | 1.23 – 5.75 | 0.01 |
| Cardiac | 3.26 | 1.35 – 7.84 | 0.009 |
| Gastrointestinal | 5.14 | 1.74 – 15.17 | <0.0001 |
| Pulmonary * | 2.06 | 0.95 – 4.46 | 0.07 |
| Pulmonary hypertension | 1.41 | 0.56 – 3.51 | 0.47 |
| Severe peripheral vascular † | 1.70 | 0.46 – 6.31 | 0.43 |
| Joint contractures | 0.89 | 0.49 – 1.63 | 0.58 |
*
interstitial lung disease or restrictive lung disease
†
defined as presence of digital ulcers or gangrene
‡
race, disease duration, baseline modified Rodnan skin score and skin thickness progression rate group