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. Author manuscript; available in PMC: 2014 Aug 22.
Published in final edited form as: Immunity. 2013 Aug 8;39(2):10.1016/j.immuni.2013.07.014. doi: 10.1016/j.immuni.2013.07.014

Figure 5.

Figure 5

Biased development toward KLRG1+ secondary effector cells is intrinsic to memory CD8+ T cells. a. Phenotype of polyclonal OVA-specific memory CD8+ T cells after VSV-OVA infection (>60 days). b. One day after transfer of bulk VSV-OVA-specific memory cells into naïve recipients, mice were infected with VSV-OVA. Phenotype of transferred OVA-specific memory cells 6 days later is shown. c. A single CD45.1 OVA-specific memory CD8+ T cell and a single CD45.1/2 OVA-specific naïve CD8+ T cell were transferred to naïve mice that were then infected with VSV-OVA. Seven days later KLRG1 and CD127 expression was analyzed on the donor populations. d. Graphs show the phenotype of 13 clones derived from single memory cells and 10 clones derived from naïve cells from one VSV-OVA experiment (20 mice). This experiment was repeated 4 times with 80 mice total.