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. Author manuscript; available in PMC: 2014 Aug 9.
Published in final edited form as: Biochem Biophys Res Commun. 2013 Jun 17;437(4):10.1016/j.bbrc.2013.06.023. doi: 10.1016/j.bbrc.2013.06.023

Figure3.

Figure3

Calreticulin negatively regulates the surface expression of Cav1.3 L-type Ca channels in tsA201 cells. Cav1.3 along with its accessory subunits β2a and α2δ were expressed in tsA201 cells either with or without calreticulin. Panel A shows the expected surface expression of Cav1.3 in tsA201 cells transfected with Cav1.3. Panel D shows cytoplasmic localization of Cav1.3 in tsA201 cells co-transfected with Cav1.3 and calreticulin. Cav1.3 staining was mainly cytoplasmic in cells transfected with Cav1.3/calreticulin (panel D) compared to cells transfected with Cav1.3 (panel A) that showed membrane localization. Panels B, C, E, and F shows the phase images and the merger respectively.