Table 1.
Clinical characteristics and laboratory parameters of CAD patients with and without PAD and control subjects.
| CAD patients without PAD (n = 331) | CAD patients with PAD (n = 213) | Control subjects (n = 328) | P value | |
|---|---|---|---|---|
| Age, y | 64.1 ± 5.97 | 64.5 ± 10.7 | 63.3 ± 8.3 | Ns |
| Male, n (%) | 182 (79%) | 175 (82%) | 272 (83%) | Ns |
| BMI, kg/m2 | 25.9 ± 2.71 | 25.7 ± 3.2 | 25.6 ± 3.1 | Ns |
| Ever-smoking, n (%) | 232 (70%)** | 142 (67%)** | 102 (31%) | P < 0.0001 |
| Hypertension, n (%) | 202 (61%)** | 164 (77%)** | 58 (18%) | P < 0.0001 |
| Diabetes, n (%) | 160 (33%)* | 70 (32%)* | 33 (10%) | P < 0.001 |
| Total cholesterol, mmol/L | 5.1 ± 1 | 4.9 ± 1.16 | 4.99 ± 1.0 | Ns |
| Triglycerides, mmol/L | 3.19 (1.19–12.8)** | 2.92 (0.83–9.6)* | 1.47 (1.15–2.06) | P < 0.0001 |
| HDL cholesterol, mmol/L | 1.27 ± 0.36 | 1.22 ± 0.73 | 1.40 ± 0.42 | Ns |
| LDL cholesterol, mmol/L | 3.17 ± 0.87 | 3.39 ± 1.23 | 3.26 ± 1.2 | Ns |
| C reactive protein, mg/dL | 1.1 (0.6–1.6)* | 1.3 (0.7–1.8)* | 0.6 (0.3–1.1) | P < 0.01 |
| sRAGE, pg/mL | 766 (474–1226)*** | 615 (370–1158)** | 1335 (936–1954) | P < 0.0001 |
*P < 0.05 versus controls; **P ≤ 0.001 versus controls, ***P < 0.05 versus CAD patients with PAD.