Table 1.

Synergy Between Metformin and Carboplatin in the Ovarian Cancer Cell Lines A2780 and SKOV3.^a

Metformin (µmol/L)	Carboplatin (µmol/L)	CI for A2780 Cell Line	CI for SKOV3 Cell Line
0.02	0.05	0.040	0.093
0.2	0.5	24.461	0.319
2	5	0.214	0.387
20	50	0.411	0.274
40	100	0.264	0.023
400	1000	0.061	0.007

^a Combination index (CI) values obtained for A2780 and SKOV3 cell lines from Figure 5A. CI < 1 indicates synergy between the 2 drugs.