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Phagocytosis of pathogenic cells by neutrophils. (A) Synthesis of defensins in neutrophils. α-Defensins are proteolytically processed to the mature form and then packaged into azurophil granules. (B) Phagocytosis of pathogenic cells. When a mature neutrophil ingests a pathogenic cell, it simultaneously evokes the fusion of azurophil granules and the phagosome, and the α-defensins then exert antimicrobial activity in the limited space.
