Table 2.

Mean Levels (±SE) of Plant Sterols, Cholesterol Precursors, Sterol/Total Cholesterol Ratios in Old Order Amish ABCG8 G574R Variant Heterozygotes (G574R) and Noncarriers (G574G)

	G574R Heterozygotes (n=110)	G574G (n=181)	Age-and Sex- Adjusted P
Plant sterols
Sitosterol, mg/dL	0.47±0.02	0.34±0.02	<0.0001
Sitosterol/chol ratio*	2.13±0.07	1.52±0.06	<0.0001
Campesterol, mg/dL	0.60±0.03	0.44±0.03	<0.0001
Campesterol/chol ratio	2.72±0.10	1.97±0.08	<0.0001
Stigmasterol, µg/dL	16.29±0.84	12.06±0.79	<0.0001
Stigmasterol/chol ratio	0.07±0.003	0.05±0.003	<0.0001
Avenasterol	1.65±0.09	1.20±0.08	<0.0001
Avena/chol ratio	7.47±0.40	5.43±0.35	<0.0001
Brassicasterol, µg/dL	26.27±1.89	22.08±1.71	0.03
Brassicasterol/chol ratio	0.12±0.008	0.010±0.006	0.008
Proxy for cholesterol absorption
Cholestanol, mg/dL	0.38±0.01	0.32±0.01	<0.0001
Cholestanol/chol ratio	1.75±0.04	1.45±0.03	<0.0001
Plant stanols
Campestanol, µg/dL	5.86±0.20	4.74±0.18	<0.0001
Campestanol/chol ratio	0.03±0.001	0.02±0.001	<0.0001
Sitostanol, µg/dL	7.80±0.28	6.39±0.25	<0.0001
Sitostanol/chol ratio, µg/mg	0.04±0.001	0.03±0.001	<0.0001
Markers of cholesterol synthesis
Lanosterol, µg/dL	15.68±0.74	18.15±0.69	0.0009
Lanosterol/chol ratio	0.08±0.003	0.08±0.003	0.007
Lathosterol, mg/dL	0.20±0.01	0.24±0.01	<0.0001
Lathosterol/chol ratio	0.95±0.05	1.12±0.04	0.0006
Desmosterol, mg/dL	0.17±0.007	0.18±0.006	0.09
Desmosterol/chol ratio	0.78±0.03	0.82±0.03	0.15
Markers of bile acid synthesis
7 α cholesterol	71.3±4.5	83.9±4.3	0.005
7 α cholesterol/chol ratio	0.33±0.02	0.38±0.02	0.02

^*Chol indicates total cholesterol; and sitosterol/chol ratio, ratio of sitosterol to total cholesterol levels.