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. Author manuscript; available in PMC: 2014 Jul 19.
Published in final edited form as: Circ Res. 2013 May 29;113(3):10.1161/CIRCRESAHA.113.301552. doi: 10.1161/CIRCRESAHA.113.301552

Figure 6. ABCB10 is upregulated in the ischemic heart and modulates Ca2+ transients.

Figure 6

A, ABCB10 protein levels in sham-operated mice and mice subjected to MI injury one week and one month following the surgery. Densitometric analysis is presented below the Western blot (n=3-4). B,C, Total cellular (B) and mitochondrial (C) heme levels in mouse hearts 1 month following MI or sham operation (n=3). D, ABCB10 protein levels in explanted human hearts with ischemic cardiomyopathy or in noncardiomyopathic control human hearts. Densitometric analysis is shown on the right. E, Heme levels in myopathic and non-myopathic human hearts (n=10). F-H, Analysis of Ca2+ transients in NRCM with ABCB10 and control siRNA: representative images (F), F/F0 as a measure of transient magnitude (n=10-11 cells from 3 coverslips) (G), and rise and decay times (n=15 cells from 4 coverslips) (H). NM, nonmyopathic; ICM, ischemic cardiomyopathy. Data are presented as mean ± SEM. * p<0.05 vs. control.