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. Author manuscript; available in PMC: 2013 Nov 5.
Published in final edited form as: Nature. 2013 Apr 3;496(7444):187–192. doi: 10.1038/nature12062

Figure 1. EM reconstruction of Tetrahymena telomerase holoenzyme and subunit localization.

Figure 1

a, Holoenzyme subunits and domains (top) and TER secondary structure (below). b, Representative class averages of negative staining EM and cryoEM images of TERT-f telomerase. c, 3D reconstruction of Teb1-f telomerase (front and side views) and class averages of affinity labeled telomerase particles. Lines with circle heads indicate attachment point of Fab (red arrows) and MS2cp (white arrow). Side-lengths of class averages in this and subsequent figures are 350 Å. d, Subunit schematic (front view).