Table 2.
Clinicopathological factor and biomarker results in hotspot versus uniform-patterned breast cancers assigned by tHb optical imaging
| Variables | Values | Total | Hotspot | Uniform | p value |
|---|---|---|---|---|---|
|
Age |
Mean(year) ± SD |
58.6 ± 12.3 |
59.9 ± 11.7 |
56.5 ± 13 |
NS
*
|
|
TNM Stage |
I |
25 |
9 |
16 |
p
= 0.01
†
|
|
II |
30 |
22 |
8 |
||
|
Tumor size |
Mean(mm) ± SD |
21.5 ± 9 |
24.8 ± 9.9 |
17.4 ± 5.6 |
p
= 0.002
*
|
|
Nuclear atypia |
High |
37 |
20 |
17 |
NS
**
|
|
Low |
5 |
3 |
2 |
||
|
Mitosis |
High |
14 |
12 |
2 |
p
= 0.01
**
|
|
Low |
28 |
11 |
17 |
||
|
Nodal status |
Positive |
10 |
4 |
6 |
NS
**
|
|
Negative |
33 |
20 |
13 |
||
|
ER |
Positive |
45 |
24 |
21 |
NS
**
|
|
Negative |
6 |
5 |
1 |
||
|
PgR |
Positive |
41 |
21 |
20 |
NS
**
|
|
Negative |
10 |
8 |
2 |
||
|
HER2 |
Positive |
6 |
4 |
2 |
NS
**
|
|
Negative |
44 |
24 |
20 |
||
| FDG SUVmax | Mean ± SD | 5 ± 3.3 | 6.6 ± 3.2 | 2.6 ± 1.7 | p = 0.0004 * |
SD, standard deviation; NS, not statistically significant; *Student’s t test; **Fisher’s exact test, †Pearson’s chi square.