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. 2013 Oct 29;13:289. doi: 10.1186/1472-6882-13-289

Table 3.

Cytotoxicity of the crude extract, fractions and compounds from E. robustum and their selectivity index (SI)

Samples Cytotoxicty (LC 50 , μg/ml)
 Selectivity index a
  C.a C.A A.f C.n S.a P.a E.f E.c
Extract and fractions
  
  
  
  
  
  
  
  
  
Crude extract
 53.45 ± 2.21
 0.04
 0.04
 0.21*
 0.08
 0.67
 0.17
 0.67
 0.67
Fraction A
 17.91 ± 1.71
 0.03
 0.09*
 0.05*
 0.01
 0.90
 0.06
 0.45
 0.45
Fraction B
 93.76 ± 25.62
 0.08
 0.22*
 0.66*
 0.66*
 0.59
 0.30
 1.17
 1.17
Compounds
  
  
  
  
  
  
  
  
  
Robusflavone A (1)
 13.20 ± 0.02
 0.05
 0.20
 0.16*
 0.05
 0.05
 0.21
 0.05
 0.05
Robusflavone B (2)
 30.42 ± 3.26
 0.24
 0.47
 0.36*
 0.47
 0.24
 0.48
 0.48
 0.24
Orostachyscerebroside A (3)
 > 100
 0.4
 0.53*
 0.53*
 0.4
 0.8
 1.59
 0.8
 0.8
Stigmasterol (4)
 54.97 ± 11.05
 0.44
 0.44
 0.85
 0.44
 0.44
 0.87
 0.22
 0.22
1-O-Heptatriacontanoylglycerol (5)
 91.52 ± 28.38
 0.37
 1.41
 0.73
 0.37
 0.73
 1.45
 0.73
 0.73
Eicosanoic acid (6)
 NT
 -
 -
 -
 -
 -
 -
 -
 -
3-O-β-D-Glucopyranoside of sitosterol (7)
 >100
 0.80
 0.80
 1.17*
 1.17*
 0.80
 1.58
 1.58
 0.80
6-Prenylpinocembrin (8)
 21.87 ± 0.37
 0.17
 0.34
 0.13*
 0.09
 0.70
 0.35
 0.35
 0.35
Control
  
  
  
  
  
  
  
  
  
Dox 3.32 ± 1.31                

C.a: Candida albicans (isolate), C.A: Candida albicans (ATCC), A.f: Apergillus fumigatus, C.n: Cryptoccocus neoformans, E.c: Escherichia coli, E.f: Enterococcus faecalis, S.a: Staphylococcus aureus, P.a: s Dox: Doxorubicin with LC50 in μM, NT: not tested, aSI = LC50 /MIC, *SI obtained from average MIC.