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. Author manuscript; available in PMC: 2014 Jun 24.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 May 17;52(26):10.1002/anie.201301815. doi: 10.1002/anie.201301815

Table 2.

Catalytic enantioselective cyclobutanone alkylation: (A) scope of α-keto substitutent tolerance; (B) functional diversity incorporated at the 2-allyl position.[a]

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[A]

Conditions cyclobutanone 4 (1.0 equiv), Pd2(pmdba)3 (5 mol%), (S)-L2 (12.5 mol%) in toluene (0.033 M) at 20 °C for 12–48 h. All reported yields are for isolated products.