Table 2.
The Distribution of Radiolabeled Particles After Delivery with Calfactant and Saline Aerosols
| Saline | Surfactant | p-value | |
|---|---|---|---|
| Distribution at t=0 | |||
| Whole lung (%) | 100 | 100 | — |
| Central lung (%) | 42±5 | 42±4 | 0.94 |
| Peripheral lung (%) | 58±5 | 58±4 | 0.94 |
| Central/peripheral ratio | 0.73±0.16 | 0.72±0.11 | 0.89 |
| Coefficient of Variation | 1.03±0.17 | 1.08±0.24 | 0.62 |
| Distribution at t=30 min | |||
| Whole lung (% ) | 92±7 | 92±10 | 0.78 |
| Central lung (% ) | 37±8 | 41±5 | 0.08 |
| Peripheral lung (% ) | 55±6 | 51±8 | 0.26 |
| Central/peripheral ratio | 0.68±0.19 | 0.82±0.12 | 0.09 |
| Coefficient of Variation | 1.09±0.18 | 1.17±0.28 | 0.48 |
| 30-min change in: | |||
| Whole lung (%) | −8±7 | −8±10 | 0.78 |
| Central lung (%) | −5±7 | 0±2 | 0.12 |
| Peripheral lung (%) | −3±5 | −8±8 | 0.29 |
| Central/peripheral ratio | −0.05±0.16 | 0.10±0.10 | 0.07 |
| Coefficient of variation | 0.06±0.06 | 0.09±0.08 | 0.57 |
Values at the beginning and end of a 30-min postdelivery imaging period are reported. Regional lung doses are expressed as a percentage of whole lung counts at the start of the imaging period. Wilcoxon matched-pairs signed-ranks test was used for comparisons. All mean±standard deviation.