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. 2013 Oct 18;10:127. doi: 10.1186/1742-2094-10-127

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Copyright © 2013 Williams et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Immunocytochemical demonstration of hBD-1 in the hippocampus. Age-matched controls (A,B) vs. AD (C,D) shows an elevated protein expression in the cytoplasm of pyramidal neurons in AD compared to non-AD control brain. The expected localization of hBD-1 in glial cells was also demonstrated in AD cases (C, inset). In AD cases, GVD is also specifically stained (D, arrows). In D, inset shows a higher magnification image of the GVD-containing neuron marked with an asterisk (*). Scale bar A–D = 50 μm; Insets C,D = 20 μm.