Table 1.
Clinical Factor | Levels |
---|---|
Clinical scenario (site of care and illness severity) | (1) Outpatient, medically stable |
(2) Inpatient, nonmonitored bed, resolving pneumonia | |
(3) Inpatient, nonmonitored bed, mild CHF exacerbation from ischemic cardiomyopathy, normal troponin | |
(4) Inpatient, monitored hospital bed, rate-controlled atrial fibrillation, on warfarin (INR=2.5), normal troponin | |
(5) Inpatient, monitored bed, chest pain, normal EKG, borderline troponin | |
Hemoglobin (g/dl) | (1) ≤7.5 |
(2) 7.6–8.0 | |
(3) 8.1–8.5 | |
(4) 8.6–9.0 | |
(5) 9.1–9.5 | |
(6) 9.6–10.0 | |
(7) >10.0 | |
Hemoglobin stability over time | (1) No change in hemoglobin level; stable over time |
(2) 0.5 g/dl drop over the past month | |
(3) 0.5 g/dl drop over the past week | |
(4) 1.0 g/dl drop over the past month | |
(5) 1.0 g/dl drop over the past week | |
Evidence of occult blood in stool | (1) Yes but no evidence of gastrointestinal bleeding |
(2) No | |
Patient transplant eligibility | (1) Ineligible |
(2) Eligible but currently unlisted | |
(3) Eligible and currently listed | |
Age (yr) | (1) <45 |
(2) 45–54 | |
(3) 55–64 | |
(4) 65–74 | |
(5) 75–84 | |
(6) ≥85 | |
ESA status | (1) Patient is on an ESA; hemoglobin is highly responsive to dosing |
(2) Patient is on an ESA; hemoglobin is only moderately responsive to dosing | |
(3) Patient is on an ESA; hemoglobin is poorly responsive to dosing | |
Functional status | (1) No limitations; no symptoms while performing ordinary physical activities like walking or climbing stairs |
(2) Mild limitations; slight shortness of breath and/or fatigue during ordinary activities like walking or climbing stairs | |
(3) Moderate limitations; shortness of breath and/or fatigue while performing even less than ordinary activities like walking short distances | |
(4) Severe limitations; shortness of breath and/or fatigue even at rest; mostly bedbound | |
Cardiovascular disease (e.g., coronary artery disease, peripheral vascular disease, history of stroke, or heart attack) | (1) No cardiovascular disease |
(2) Single cardiovascular morbidity | |
(3) Multiple cardiovascular morbidities | |
Iron indices | (1) Iron deficiency (e.g., low iron, TSAT<20%, ferritin<100 ng/ml) |
(2) Iron replete (e.g., normal iron, TSAT>20%, ferritin>200 ng/ml) | |
(3) Chronic disease (e.g., low iron, TIBC>300, ferritin>500 ng/ml) |
CHF, congestive heart failure; INR, international normalized ratio; EKG, electrocardiogram; ESA, erythropoiesis-stimulating agent; TSAT, transferrin saturation; TIBC, total iron-binding capacity.