Table 2.
Patient characteristics, stratified by day of initiation of dialysis
| Variable | Sunday Initiation (n=52) | Monday Initiation (n=71) | Tuesday–Saturday Initiation (n=411) | P Value (Sunday versus Monday) | P Value (Sunday versus Tuesday–Saturday) |
|---|---|---|---|---|---|
| Demographics | |||||
| Age (yr) | 59±16 | 56±17 | 59±16 | 0.30 | 0.96 |
| Men | 31 (60) | 50 (70) | 259 (63) | 0.21 | 0.63 |
| Black | 10 (19) | 13 (18) | 70 (17) | 0.90 | 0.69 |
| Hospital location | |||||
| Surgical service | 28 (54) | 46 (65) | 234 (57) | 0.22 | 0.67 |
| Intensive care unit | 50 (96) | 65 (92) | 363 (88) | 0.32 | 0.10 |
| Dialytic modality | |||||
| CRRTa | 40 (77) | 56 (79) | 274 (67) | 0.80 | 0.14 |
| IHD | 12 (23) | 15 (21) | 137 (33) | ||
| Comorbid conditions (present at admission) | |||||
| HIV | 1 (2) | 0 (0) | 7 (2) | n/a | 0.91 |
| Congestive heart failure | 21 (40) | 30 (42) | 189 (46) | 0.84 | 0.45 |
| Cardiovascular disease | 10 (19) | 10 (14) | 39 (9) | 0.45 | 0.04 |
| Diabetes | 15 (29) | 20 (28) | 102 (25) | 0.93 | 0.53 |
| Liver disease | 19 (37) | 26 (37) | 176 (43) | 0.99 | 0.39 |
| Malignancy | 7 (13) | 6 (8) | 37 (9) | 0.38 | 0.31 |
| Metastatic solid tumor | 1 (2) | 2 (3) | 17 (4) | 0.75 | 0.45 |
| Myocardial infarction | 8 (15) | 16 (23) | 71 (17) | 0.33 | 0.73 |
| Peptic ulcer disease | 2 (4) | 4 (6) | 19 (5) | 0.65 | 0.80 |
| Peripheral vascular disease | 7 (13) | 18 (25) | 77 (19) | 0.11 | 0.36 |
| Pulmonary disease | 6 (12) | 6 (8) | 51 (12) | 0.57 | 0.86 |
| Hemiplegia | 1 (2) | 3 (4) | 10 (2) | 0.49 | 0.82 |
| Rheumatologic disease | 1 (2) | 4 (6) | 8 (2) | 0.33 | 0.99 |
| Laboratory values | |||||
| Baseline creatinine (mg/dl) | 0.96±0.27 | 0.94±0.27 | 0.94±0.25 | 0.75 | 0.68 |
| Bicarbonate (mEq/L) | 17±5 | 17±5 | 17±5 | 0.51 | 0.89 |
| BUN (IQR) (mg/dl) | 56 (44–96) | 74 (53–108) | 66 (41–96) | 0.02 | 0.34 |
| Change in creatinine from day prior (IQR) (mg/dl) | 0.80 (0.50–1.22) | 0.80 (0.44–1.14) | 0.83 (0.50–1.40) | 0.41 | 0.91 |
| Creatinine (mg/dl) | 4.01±2.03 | 4.26±1.61 | 4.18±1.81 | 0.45 | 0.54 |
| Potassium (mEq/L) | 5.2±0.9 | 5.1±1.0 | 5.3±1.1 | 0.59 | 0.75 |
| AKI data | |||||
| Hospital stay prior to today (IQR) (d) | 7.5 (4–12.5) | 8 (4–17) | 8 (4–14) | 0.30 | 0.63 |
| Onset of AKI to doubling of creatinine (IQR) (d) | 2 (1–2) | 2 (1–2) | 2 (1–2) | 0.69 | 0.65 |
| Time from AKI stage 2 to RRT (IQR) (d) | 2 (1–3) | 3 (2–5) | 2 (1–5) | 0.05 | 0.17 |
| Acuity of illness | |||||
| SOFA score | 11.8±2.9 | 10.8±2.8 | 10.8±3.4 | 0.08 | 0.06 |
| Ventilated | 41 (79) | 52 (73) | 269 (65) | 0.48 | 0.06 |
| Pressor requirement | |||||
| None | 8 (15) | 20 (28) | 141 (34) | 0.10 | 0.01 |
| 1 | 12 (23) | 12 (17) | 62 (15) | 0.39 | 0.14 |
| ≥2 | 32 (62) | 39 (55) | 208 (51) | 0.46 | 0.14 |
| Propensity to be dialyzed | 0.33±0.27 | 0.24±0.18 | 0.26±0.23 | 0.02 | 0.03 |
Data are mean ± SD or n (%) unless otherwise indicated (n=patients). CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis; IQR, interquartile range; SOFA, Sequential Organ Failure Assessment.
a
At the study institutions during the time course of this study, all CRRT was performed as continuous venovenous hemodialysis.