Table 2.
Associations to natural log-erythropoietin resistance index
| Predictor | Univariate Analysis Difference in Log-ERI (95% CI) | P Value | Multivariable Model 1 Difference in Log-ERI (95% CI) | P Value | Multivariable Model 2 Difference in Log-ERI (95% CI) | P Value |
|---|---|---|---|---|---|---|
| Carbamylation | ||||||
| Quartile 4 versus 1 | 0.51 (0.04 to 0.96) | 0.03a | 0.55 (0.15 to 0.95) | 0.01b | 0.66 (0.22 to 1.10) | 0.004c |
| Quartile 3 versus 1 | 0.08 (−0.37 to 0.54) | 0.71a | 0.06 (−0.35 to 0.48) | 0.75b | 0.20 (−0.27 to 0.67) | 0.40c |
| Quartile 2 versus 1 | −0.29 (−0.74 to 0.16) | 0.20a | −0.21 (−0.60 to 0.19) | 0.30b | −0.16 (−0.59 to 0.28) | 0.47c |
| Age, yr | 0.01 (−0.01 to 0.02) | 0.43 | −0.01 (−0.02 to 0.01) | 0.63 | ||
| Women | −0.11 (−0.44 to 0.22) | 0.51 | −0.24 (−0.58 to 0.10) | 0.17 | ||
| White race | −0.08 (−0.44 to 0.27) | 0.64 | 0.06 (−0.26 to 0.39) | 0.70 | ||
| Urea reduction ratio | 0.01 (−0.02 to 0.03) | 0.65 | 0.01 (−0.03 to 0.03) | 0.91 | ||
| Hemoglobin (g/dl) | −0.32 (−0.43 to −0.22) | <0.001 | −0.27 (−0.38 to −0.17) | <0.001 | −0.27 (−0.38 to −0.16) | <0.001 |
| Parathyroid hormoned (pg/ml) | −0.18 (−0.38 to 0.01) | 0.07 | −0.06 (−0.23 to 0.11) | 0.48 | −0.05 (−0.25 to 0.14) | 0.58 |
| Albumin (g/dl) | −1.0 (−1.42 to −0.65) | <0.001 | −0.58 (−0.95 to −0.22) | 0.002 | −0.51 (−0.91 to −0.11) | 0.01 |
| Ferritind (ng/ml) | −0.23 (−0.40 to −0.06) | 0.01 | −0.10 (−0.26 to 0.06) | 0.23 | −0.08 (−0.25 to 0.10) | 0.38 |
| Transferrin saturation (%) | −0.04 (−0.05 to −0.02) | <0.001 | −0.03 (−0.04 to −0.01) | <0.001 | −0.03 (−0.05 to −0.01) | <0.001 |
| Received intravenous iron therapy | −0.43 (−0.87 to 0.01) | 0.06 | −0.27 (−0.64 to 0.10) | 0.15 | −0.26 (−0.68 to 0.16) | 0.22 |
| Body mass index | −0.04 (−0.06 to −0.02) | <0.001 | −0.02 (−0.04 to −0.01) | 0.01 | −0.02 (−0.05 to 0.00) | 0.04 |
| Vascular access (catheter) | −0.26 (−0.61 to 0.08) | 0.13 | −0.08 (−0.42 to 0.27) | 0.67 | ||
| IL-6d (pg/ml) | 0.12 (−0.01 to 0.25) | 0.06 | −0.07 (−0.18 to 0.03) | 0.18 | −0.08 (−0.21 to 0.05) | 0.22 |
| Myeloperoxidase (ng/ml) | 0.01 (−0.01 to 0.01) | 0.62 | 0.01 (−0.00 to 0.01) | 0.68 |
Effect estimates of the association between various predictors and the natural log-erythropoietin resistance index (log-ERI) in univariate and multivariable analysis. Difference in log-ERI (95% confidence interval [95% CI]) represents the difference in the log-ERI per unit change in the predictor (95% CI). Adjusted model 1 includes only variables significant in univariate analysis at P<0.10. Adjusted model 2 includes all variables from the univariate analysis.
a
P for overall trend across all quartiles=0.01.
b
P for overall trend across all quartiles=0.002.
c
P for overall trend across all quartiles=0.001.
d
Variable log-transformed.