Table 5: Results for Seizure Frequency Stratified by Age, Epilepsy Type, and Seizure Location.
| Study | Partial Seizures | Stratified by Region of Seizure Origin | Other |
|---|---|---|---|
| DBS in adults | |||
| Fisher et al, 2010 (SANTE) (6) |
Complex partial seizures Mean seizure frequency from baseline Stimulation: reduction, 36.3% Control: reduction, 12.1% P = 0.041 (outlier removed) |
One or both temporal regions Median seizure reduction from baseline Stimulation: reduction, 44.2% Control: reduction, 21.8% P = 0.025 | Previous VNS or surgery: comparable results to those without history of surgery or VNS. No data provided. |
| Frontal, parietal, or occipital regions did not demonstrate a significant difference in seizure reduction between stimulated and control groups | |||
| Multifocal/diffuse seizure origin 35.0% seizure reduction in stimulated group versus 14.1% reduction in control group P = NS but study not powered to detect difference, with only 8 in stimulated group and 9 controls | |||
| VNS in adults | |||
| DeGiorgio et al, 2005 (7) | No results reported by epilepsy type or seizure location | ||
| Handforth et al, 1998 (E05 study) (8) | Partial onset seizures with alteration of consciousness Mean reduction: High: 26.6; SD, 36.8 Low: 13.4%; SD, 40.1; P = 0.03 |
Not reported | Not applicable |
| Clarke et al, 1997 (9) | No results reported by epilepsy type or seizure location | ||
| Vagus Nerve Stimulation Study Group, 1995 (E03 study) (10) | Complex partial seizures Mean seizure frequency from baseline: High: reduction, 24.0% Low: reduction, 12.5% P = 0.08 (ITT) |
Not reported | Not applicable |
| VNS in children | |||
| Klinkenberget al, 2012 (11) | No results reported by epilepsy type or seizure location | ||
Abbreviations: High, high stimulation group; ITT, intent-to-treat; Low: low stimulation group; NS, not significant; VNS, vagus nerve stimulation.