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. 2013 Nov 15;140(22):4510–4521. doi: 10.1242/dev.090738

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© 2013. Published by The Company of Biologists Ltd

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Fig. 7. — Regeneration of retinal ganglion cells is reduced in cdh2⁺^/^m117 heterozygotes. (A,C) At 3 dpi, GFP⁺/N-cadherin⁺ (white/magenta) basal Müller glia processes collapse in siblings (A) and hets (C). (B,D) N-cadherin⁺ (white/magenta) neurogenic clusters in sib retinas (B, arrows) and abnormal clusters in hets (D) at 5 dpi. (E) Regenerated nGFP⁺/Rx1^-/HuC/D⁺ (red) inner retinal neuron (boxed; enlarged in inset) in het at 5 dpi. (F) Counts of PCNA⁺ cells in sib and cdh2⁺^/^m117. (G) HuC/D⁺ (magenta) neurons are destroyed at 1 dpi; some regenerate by 14 dpi. (H) Regenerated HuC/D⁺ neurons in hets. (I) Counts of HuC/D⁺ neurons. ^*P<0.0001. Box plots: median, 25th and 75th percentiles; whiskers show maximum and minimum data points. Scale bars: 20 μm.