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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2013 Jun 19;230(3):10.1007/s00213-013-3166-x. doi: 10.1007/s00213-013-3166-x

Figure 2. Increased sensitivity to alcohol reward in Arrb2 knockout mice.

Figure 2

Wt and mice lacking Arrb2 were tested in the CPP paradigm to assess to role of Arrb2 in mediating the rewarding effects of alcohol (2A). Data represent time spent in the alcohol (alc) or saline (sal) paired compartment in seconds (mean ± S.E.M.). A dose of 1.0 g/kg alcohol did not induce place preference in wt mice. However, Arrb2 knockout mice spent significant more time in the alcohol vs. saline compartment, ***p<0.001. (2B) Locomotion in both compartments during the whole CPP session is expressed in cm (mean ±S.E.M.). Arrb2 knockouts but not wt mice moved significantly more in the alcohol paired compartment compared to the saline compartment, while total locomotion was not different between genotypes **p<0.01. n = 10-13/group.