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Type I collagen fibril structure and nanomorphological heterogeneity. (a) The proposed quasi-hexagonal packing at fibril cross-section, adapted from Hulmes et al.20 with permission. (b) TEM studies in the 1940s showing nanomorphological variations result in a D-spacing distribution, adapted from Gross and Schmitt14 with permission. (c) Significant alteration of D-spacing distribution in the OVX ovine bone, adapted from Wallace et al.12 with permission.
