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. 2013 Oct 22;3(10):e318. doi: 10.1038/tp.2013.90

Figure 2.

Figure 2

Rhythm modulation by Li is associated with clock gene variants. (a) Period lengthening after Li 1 mM for RORA rs12912233 homozygous common (T/T), heterozygous (C/T) and homozygous variant (C/C) genotypes [N=5/11/3 (controls), N=7/9/3 (BD), P<0.05]. (b) Period lengthening after Li 10 mM for PER3 rs228729 homozygous common (T/T), heterozygous (T/C) and homozygous variant (C/C) genotypes [N=6/12/1 (controls), N=11/6/2 (BD), P<0.001]. In both cases (a,b), genotype effects were significant regardless of diagnosis so BD cases and controls have been combined. (c) Amplitude increase after Li 1 mM among GSK3β −50T/C homozygous common (T/T) and rare variant carriers (T/C and C/C). Two-way ANOVA revealed a significant genotype × diagnosis interaction (P<0.05), but no significant difference between genotypes or diagnoses alone. (d) Period lengthening after Li 10 mM. Two-way ANOVA revealed effect of BD (P<0.05), and significant genotype × diagnosis interaction (P<0.001). For homozygous common/heterozygous/homozygous variant genotypes, N=8/11/0 (controls) and N=9/9/1 (BD), respectively. Error bars indicate s.e.m.