Table 1. Clock gene SNPs and MAF in BD cases and controls.
Gene | SNP | MAF Cont | MAF BD | Notes |
---|---|---|---|---|
BMAL1 | rs2279287 | 31.6 | 13.2 | Assoc BD, AKA ARNTL38 |
CLOCK | rs1801260 | 31.6 | 26.3 | Assoc BD and insomnia32 |
CRY1 | rs8192440 | 26.3 | 28.9 | Assoc Li response18 |
CRY2 | rs2037311 | 2.6 | 2.6 | |
CSNK1E | rs1534891 | 13.2 | 10.5 | |
GSK3β | rs334558 | 28.9 | 28.9 | Assoc Li response13, 14 |
NPAS2 | rs11541353 | 18.4 | 23.7 | Assoc SAD, AKA S471L33 |
Rev-Erbα | rs2071427 | 18.4 | 18.4 | Assoc Li response,18 AKA NR1D1 |
PER1 | rs3027178 | 15.8 | 26.3 | |
PER2 | rs56013859 | 15.8 | 26.3 | Assoc SAD,33 AKA 10870 |
PER3 | rs228729 | 36.8 | 26.3 | Assoc BD,38 tags VNTR |
RORA | rs12912233 | 44.7 | 39.5 | Assoc depression31 |
Abbreviations: Assoc, associated; AKA, also known as; MAF, minor allele frequency; SAD, seasonal affective disorder; SNP, single-nucleotide polymorphism; VNTR, variable number tandem repeat.
In some instances, past illness associations and reference are indicated. Also known as (AKA) indicates alternate name for SNP or gene.