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. Author manuscript; available in PMC: 2013 Nov 5.
Published in final edited form as: Cancer Cell. 2010 Dec 14;18(6):10.1016/j.ccr.2010.10.034. doi: 10.1016/j.ccr.2010.10.034

Figure 3. Chk2 is required for radiation response in gliomas in vivo.

Figure 3

Percentage of (A) TUNEL (24h post 10Gy IR) and (B) pH3 (3h and 24h post 10Gy IR) positive glioma cells in tumor-bearing mice of the indicated genotype; Student t-test (A) ** p=0.0023, *** p=0.007 and (B) ## p=0.0089 (Chk2−/− vs. WT). Data are presented as mean ± SD of 3 tumors for each group. (C) and (D) Kaplan-Meier survival curves of RCAS/PDGF-induced gliomas in Ntv-a and Ink4a/Arf−/− and Ntv-a Chk2−/− mice, respectively; black arrows indicate the day of exposure to 10Gy IR. Log-rank p values have been measured with the Mantle-Cox test.