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. Author manuscript; available in PMC: 2013 Nov 5.
Published in final edited form as: J Immunol. 2007 Jan 15;178(2):1158–1163. doi: 10.4049/jimmunol.178.2.1158

FIGURE 5.

FIGURE 5

Effect of endotoxin on the CRP-mediated protection of mice infected with S. pneumoniae. Mice were injected with 0.5 × 108 CFU bacteria, with 150 μg of either WT or F66A/E81A CRP. Control groups A and B received 150 μl of TBS. The endotoxin levels (EU) are given in the parentheses. TBS or CRP was injected first; bacteria were injected 30 min later. Deaths were recorded twice per day for 10 days. Six male mice were used in all groups. The p values for the differences in the survival curves among groups A and B, A and C, A and D, and C and D are 0.30, 0.01, 0.004, and 0.87, respectively.