Table 1.
MetaCore Pathway Analysis
| Biological Process |
Probe Set ID |
Gene Symbol |
Transcript description | Fold change TLM (% of DMSO) |
p-value | Fold change TLM+AML (% of DMSO) |
p-value |
|---|---|---|---|---|---|---|---|
| Cell cycle | 8124492 | HIST1H2BK | histone cluster 1, H2bk | −46 | 0.002 | −39 | 0.01 |
| 7968637 | CCNA1 | Cyclin A1 | −17 | 0.02 | −24 | 0.01 | |
| 7983969 | CCNB2 | Cyclin B2 | −10 | ns | −27 | 0.01 | |
| 8043602 | NCAPH | non-SMC condensin I complex, subunit H |
−12 | 0.03 | −22 | 0.01 | |
| 8067167 | AURKA | Aurora-A | −13 | 0.06 | −19 | 0.02 | |
| 8156290 | CKS2 | CDC28 protein kinase regulatory subunit 2 |
−14 | ns | −18 | 0.01 | |
| 7987636 | OIP5 | Opa interacting protein 5 | −11 | 0.03 | −17 | 0.02 | |
| 7899688 | KPNA6 | Importin (karyopherin)-alpha 6 | −8 | 0.03 | −9 | 0.0001 | |
| 8053610 | ANAPC1 | anaphase promoting complex subunit 1 | 9 | 0.01 | 7 | 0.01 | |
|
| |||||||
|
Apoptosis
and survival |
8098576 | SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
−12 | 0.01 | −14 | 0.07 |
| 8114145 | VDAC1 | Voltage-dependent anion channel 1 | −12 | 0.02 | −14 | 0.02 | |
| 8042335 | VDAC2 | Voltage-dependent anion channel 2 | −9 | ns | −13 | 0.01 | |
| 7967230 | DIABLO | Smac/Diablo | −7 | 0.04 | −12 | 0.02 | |
| 7973377 | BCL2L2 | Apoptosis regulator Bcl-W | 10 | 0.02 | 5 | 0.06 | |