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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Eur Biophys J. 2013 Sep 1;42(10):10.1007/s00249-013-0925-x. doi: 10.1007/s00249-013-0925-x

Fig. 11.

Fig. 11

Protein-protein crystal contacts can lead to structural perturbations. a) The acid sensing ion channel (ASIC; 2QTS) has a three-fold pseudo-symmetric water soluble domain and a distorted asymmetric TM domain. The contacts between monomers are boxed and highlighted in (c). b) 5-lipoxygenase (2Q7M) is also a trimer and one of the four helices forms crystal contacts with a neighboring trimer leading to what appears to be a shift in the TM helix of nearly 10Å out of the hydrophobic environment and for a hydrophilic interhelical loop to penetrate nearly 10Å into the membrane.