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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2013 Sep 14;72(5):10.1007/s00280-013-2283-x. doi: 10.1007/s00280-013-2283-x

Table 1.

Pharmacokinetic parameter estimates for nilotinib after p.o. administration of nilotinib alone and with co-administration of calcium carbonate (N = 11)

Parameter Unit Nilotinib Nilotinib + Ca p-value
AUC0-inf (μg/mL•h) 18.4 (7.5) 16.9 (8.2) 0.831
Cmax (μg/mL) 0.670 (0.351) 0.618 (0.273) 0.966
tmax (h) 4.3 (1.7) 5.6 (2.5) 0.117
t1/2 (h) 18.9 (5.9) 17.2 (9.1) 0.182
Vss/F (L) 714 (275) 739 (330) 0.898
Cl/F (L/h) 24.9 (9.2) 28.7 (13.9) 0.765

The data are expressed as mean (standard deviation).

The percentage of the AUC0–∞ extrapolated beyond Clast was <26% (average 7.7%).