Table 3.
Changes in selected characteristics of the participants, categorized by median of DNA SERPINE1 CpG 10 methylation (≤ or >7%) at baseline
| Characteristics | Lower DNA SERPINE1 methylation % (n = 23) | Higher DNA SERPINE1 methylation % (n = 23) | p value |
|---|---|---|---|
| Energy intake (kcal) | –717 ± 107 | –882 ± 121 | 0.311 |
| Body weight (kg) | –5.90 ± 2.53 | –7.82 ± 2.68 | 0.016 |
| BMI (kg/m2) | –2.22 ± 0.20 | –2.64 ± 0.20 | 0.143 |
| Waist circumference (cm) | –6.07 ± 0.69 | –7.28 ± 0.95 | 0.308 |
| Triceps skinfold (mm) | –2.01 ± 0.79 | –4.53 ± 1.08 | 0.065 |
| Bioimpedance Total Fat mass (%) | –1.84 ± 0.48 | –4.11 ± 0.68 | 0.009 |
| Bioimpedance Total Fat mass (kg) | –3.96 ± 0.46 | –7.06 ± 0.89 | 0.003 |
| DXA Total Fat mass (%) | –1.84 ± 0.42 | –2.45 ± 0.42 | 0.309 |
| DXA Trunk Fat mass (%) | –2.07 ± 0.68 | –3.62 ± 0.52 | 0.077 |
| DXA Android Fat mass (%) | –1.96 ± 0.81 | –4.68 ± 0.79 | 0.021 |
| DXA Total Fat mass (kg) | –4.28 ± 0.51 | –5.68 ± 0.51 | 0.060 |
| Glucose (mg/dl) * | –1.31 ± 0.54 | –1.03 ± 0.54 | 0.120 |
| Insulin (µU/ml) * | –0.53 ± 0.50 | –0.79 ± 0.33 | 0.066 |
| HOMA-IR* | –0.19 ± 0.45 | –0.19 ± 0.48 | 0.951 |
| Total cholesterol (mg/dl) * | –1.2 ± 0.6 | –1.4 ± 0.4 | 0.048 |
| HDL-c (mg/dl) | –3.6 ± 6.1 | –2.8 ± 6.8 | 0.688 |
| Triglycerides (mg/dl)* | –1.4 ± 0.5 | –1.8 ± 0.5 | 0.011 |
| SBP (mmHg) | –11 ± 4 | –15 ± 4 | 0.515 |
| DBP (mmHg) | –5 ± 2 | –8 ± 2 | 0.218 |
| CRP (mg/l)* | –0.10 ± 0.78 | –0.20 ± 0.71 | 0.746 |
| PAI-1 (ng/ml) | –38.72 ± 23.24 | –49.77 ± 15.48 | 0.692 |
| IL-6 (pg/ml)* | 0.43 ± 0.53 | 0.28 ± 0.62 | 0.550 |
| TNF-α (pg/ml) | –0.01 ± 0.08 | –0.14 ± 0.08 | 0.245 |
Data are mean ± SD. p values from Student t test. *Log transformed variables. BMI, body mass index; DXA, dual-energy x-ray absoptiometry; HOMA-IR, homeostasis model assessment-insulin resistance; HDL-c, high density lipoprotein cholesterol; SBP, systolic blood pressure; DBP, diastolic blood pressure; CRP, c-reactive protein; PAI-1, plasminogen activator inhibitor-1; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α.