Table 1. Survival analysis according to clinical features and type of therapy in patients with ATC.
| Prognostic factors | Univariate analysis |
Multivariate analysis |
||||||
|---|---|---|---|---|---|---|---|---|
| Median Survival (months) | 1-year OS (%) | 3-year OS (%) | P | HR | 95% CI | P | ||
| Sex | ||||||||
| Men (n = 28) | 5 | 32.1 | 21.4 | 0.684 | ||||
| Women (n = 32) | 8 | 37.5 | 24.3 | 0.879 | 0.469-1.646 | 0.686 | ||
| Age | ||||||||
| < 55 years (n = 26) | 15 | 53.8 | 38.5 | 0.033 | ||||
| ≥ 55 years (n = 34) | 6 | 20.6 | 11.0 | 1.829 | 0.984-3.397 | 0.056 | ||
| Primary tumor size | ||||||||
| < 6 cm (n = 31) | 8 | 29.0 | 15.1 | 0.396 | ||||
| ≥ 6 cm (n = 29) | 11 | 41.4 | 31.0 | 1.075 | 0.566-2.044 | 0.825 | ||
| Lymph node metastasis | ||||||||
| N0 (n = 24) | 8 | 37.5 | 28.6 | 0.230 | ||||
| N1 (n = 36) | 6 | 33.3 | 19.4 | 1.206 | 0.619-2.349 | 0.582 | ||
| Distant metastasis | ||||||||
| M0 (n = 44) | 8 | 38.6 | 29.1 | 0.032 | ||||
| M1 (n = 16) | 3 | 25.0 | 6.3 | 0.607 | 0.129-2.845 | 0.526 | ||
| Stage (AJCC, 2010) | ||||||||
| IVA (n = 4) | 86 | 100.0 | 75.0 | 0.030 | ||||
| IVB (n = 40) | 8 | 32.5 | 24.5 | 1.798 | 0.486-6.655 | 0.379 | ||
| IVC (n = 16) | 3 | 25.0 | 6.3 | |||||
| WBC count | ||||||||
| < 10.0 × 109/L (n = 38) | 11 | 44.7 | 33.8 | 0.006 | ||||
| ≥ 10.0 × 109/L (n = 22) | 3 | 18.2 | 4.5 | 2.105 | 0.962-4.605 | 0.062 | ||
| *PLT count | ||||||||
| < 300.0 × 109/L (n = 30) | 8 | 33.3 | 25.9 | 0.025 | ||||
| ≥ 300.0 × 109/L (n = 12) | 3 | 16.7 | 0.00 | |||||
| Surgery type | ||||||||
| None (n = 19) | 6 | 31.6 | 15.8 | 0.998 | ||||
| Thyroidectomy alone (n = 25) | 7 | 32.0 | 27.4 | 1.219 | 0.823-1.804 | 0.323 | ||
| Thyroidectomy plus neck dissection (n = 16) | 11 | 43.8 | 25.0 | |||||
| Chemotherapy | ||||||||
| Yes (n = 20) | 6 | 20.0 | 10.0 | 0.046 | ||||
| No (n = 40) | 9 | 42.5 | 29.5 | 1.310 | 0.689-2.488 | 0.410 | ||
| Radiotherapy | ||||||||
| None or dose < 40 Gy (n = 37) | 5 | 24.3 | 15.4 | 0.014 | ||||
| Dose ≥ 40 Gy (n = 23) | 14 | 52.2 | 34.8 | 1.140 | 0.506-2.566 | 0.752 | ||
| Therapeutic regimen | ||||||||
| Surgery plus postoperative radiotherapy (n = 15) | 27 | 73.3 | 46.7 | 0.002 | ||||
| Other therapy (n = 45) | 5 | 22.2 | 15.0 | 0.448 | 0.190-1.058 | 0.067 | ||
Abbreviations: ATC, anaplastic thyroid carcinoma; OS, overall survival; HR, hazard ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer; WBC, white blood cell; PLT, blood platelet.
*Because 18 patients did not receive PLT count examination at presentation, so only the other 42 cases were used to analyze the relationship between PLT count and prognosis.