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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: J Immunol. 2013 Oct 4;191(10):10.4049/jimmunol.1301253. doi: 10.4049/jimmunol.1301253

Figure 1.

Figure 1

CD28−/− NOD.H-2h4 mice have fewer Treg than WT NOD.H-2h4 mice. CD4+FoxP3+ cells in spleens and lymph nodes of WT and CD28−/− NOD.H-2h4 mice were determined by flow cytometry. Dot plots of representative mice from each group indicating the percentages of splenic CD4+ cells that express FoxP3 are shown (top). Data are shown as mean ± SEM of N = 6(Spleen B−/− and CD28−/−B−/−) and 3(LN B−/− and CD28−/−) per group and are pooled from 2 experiments. ** p<0.01 compared with respective control CD28+ group, Student’s t-test.