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. 2013 Oct 17;10:64. doi: 10.1186/1743-7075-10-64

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Copyright © 2013 Tzeng et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of treatments on renal TGF-β1 and fibronectin protein expression. (A) Representative immunoblots of protein expression of TGF-β1 and fibronectin in renal tissues of STZ-diabetic rats treated for eight weeks with zerumbone (ZER) or rosiglitazone (RGZ). STZ-diabetic rats were dosed by oral gavage once daily for eight weeks with 20 mg/kg ZER (ZER 20), 40 mg/kg ZER (ZER 40) or 5 mg/kg RGZ (RGZ). Normal (normal + VEH) or STZ-diabetic rats receiving vehicle treatment (STZ + VEH) were administered the same volume of vehicle (VEH) used to dissolve test medications. (B) Ratios of TGF-β1/β-actin and fibronectin/β-actin are expressed as the mean with SD (n = 4 per group) in each column. ^ap < 0.01 and ^bp < 0.01 compared to vehicle-treated normal rats. ^cp < 0.05 and ^dp < 0.01 compared to vehicle-treated STZ-diabetic rats, respectively.