Table 2. Lofexidine dose-ranging studies.

The acute effects of pretreatment with lofexidine (0.032–0.32 mg/kg, IM) on cocaine self-administration and food-maintained behavior in individual monkeys

Monkey	Lofexidine (mg/kg)	1 Inj	2 Inj	3 Inj	4 Inj	Total Inj	Food 1 Pellets	Food 2 Pellets
R-009	0	9 (± 4)	7 (± 5)	11 (± 5)	11 (± 4)	37 (± 13)	12 (± 6)	16 (± 1)
	0.032	14	16	17	13	60	12	10
	0.1	0	0	0	0	0	10	9
	0.32	0	0	0	0	0	14	9
R-082	0	10 (± 3)	11 (± 1)	9 (± 2)	9 (± 2)	39 (± 4)	13 (± 2)	0 (± 0)
	0.032	-	-	-	-	-	-	-
	0.1	1	10	13	12	36	0	0
	0.32	0	4	13	11	28	0	0
R-105	0	7 (± 4)	7 (± 1)	6 (± 2)	5 (± 1)	25 (± 5)	16 (± 1)	0 (± 0)
	0.032	5	7	4	4	20	13	11
	0.1	0	0	0	0	0	10	10
	0.32	0	0	0	0	0	10	11
R-166	0	12 (± 9)	7 (± 3)	8 (± 4)	10 (± 2)	37 (± 16)	15 (± 0)	13 (± 1)
	0.032	-	-	-	-	-	-	-
	0.1	14	13	14	12	53	15	9
	0.32	0	0	0	0	0	10	11