Figure 3. Induction of autophagy by ¹²⁵I was dependent on PERK-eIF2α signal pathway.

(A) Neural cells were treated with ¹²⁵I for 5 days and tunicamycin (TUN) for 24 h. The levels of protein from PERK-eIf2α pathway were measured by immunoblot analyses. Results shown in each panel were representative of at least three independent experiments. (B) Quantification of the levels of protein from PERK-eIf2α pathway in neural cells following 24 h of treatment with tunicamycin (TUN) or ¹²⁵I. Neuron cells treated with TUN were as positive controls and the untreated neurons were as negative controls (NSC-0). Data were representative of mean ± SEM. *, statistically significance in one-way anova test; *, P<0.05; **, P<0.005; ***, P<0.0005.