Table 6a. Sensitivity and specificity for MDD diagnosis across various cut-off points of the PHQ-9 by sex.
Sensitivity (95%CI) | Specificity (95%CI) | Youden Index | LR+(95%CI) | LR- (95%CI) | PPV (95%CI) | NPV (95%CI) | |
All participants | |||||||
Score≥9 | 90.4 (82.6-95.5) | 61.7 (55.6-67.5) | 52.1 | 2.6 (2.0-2.8) | 0.2 (0.1-0.3) | 45.2 (38.0-52.6) | 94.9 (90.5-97.6) |
Score≥10 | 86.2 (77.5-92.4) | 67.3 (61.3-72.9) | 53.5 | 2.6 (2.2- . 3.2) | 0.2 (0.1-0.3) | 47.9 (40.2-55.7) | 93.3 (88.8-96.4) |
Score≥11 | 78.7 (69.1-86.5) | 74.0 (68.3-79.1) | 52.7 | 3.4 (3.0-3.9) | 0.3 (0.2-0.5) | 54.3 (45.3-63.2) | 89.4 (84.8-93.0) |
Women | |||||||
Score≥9 | 90.1 (80.7-95.9) | 62.0 (54.0-69.6) | 52.1 | 2.4 (1.9-2.9) | 0.2 (0.1-0.3) | 51.0 (42.5-60.7) | 93.3 (86.7-97.3) |
Score≥10 | 85.9 (75.6-93.0) | 68.4 (60.5-75.5) | 54.3 | 2.9 (2.5-3.5) | 0.2 (0.1-0.4) | 55.0 (45.2-64.4) | 91.5 (85.0-95.9) |
Score≥11 | 81.7 (70.7-89.9) | 72.2 (64.5-79.0) | 53.9 | 2.9 (2.2-3.9) | 0.3 (0.1-0.4) | 56.9 (46.7-66.6) | 89.8 (83.1-94.4) |
Men | |||||||
Score≥9 | 91.3 (72.0-98.9) | 61.3 (51.5-70.4) | 52.6 | 2.4 (1.8-3.1) | 0.2 (0.1-0.5) | 32.8 (21.6-45.7) | 97.1 (90.1-99.7) |
Score≥10 | 87.0 (66.4-97.2) | 65.8 (56.2-74.5) | 52.8 | 2.5 (1.9-3.4) | 0.2 (0.1-0.6) | 34.5 (22.5-48.1) | 96.1 (88.9-99.2) |
Score≥11 | 69.6 (47.1-86.8) | 76.6 (67.6-84.1) | 46.1 | 2.9 (1.9-4.6) | 0.4 (0.2-0.7) | 38.1 (23.6-54.4) | 92.4 (84.9-96.9) |
LR+: positive likelihood ratio, LR-: negative likelihood ratio, PPV: positive predictive value, NPV: negative predictive value