Table 3.
Percentage Reporting Moderate or Severe Side Effects in the Past 24 Hours at 1-Month by Intervention Arm.
| MEAN (SD) |
||||
|---|---|---|---|---|
| Side Effecta | NRT (n=104) | Varenicline (n=111) | Placebo (n=33) | p = b |
| Angry, irritable, frustrated | 28.9% | 16.2% | 30.3% | .059 |
| Anxious, nervous | 33.7% | 19.8% | 33.3% | .057 |
| Depressed mood, sad | 29.8% | 15.3% | 21.2% | .041 |
| Increased appetite, hungry, weight gain | 22.1% | 11.7% | 21.2% | .115 |
| Insomnia, sleep problems, awakening | 36.5% | 35.1% | 36.4% | .976 |
| Dizziness | 4.8% | 1.8% | 3.0% | .483 |
| Coughing | 20.2% | 10.8% | 6.1% | .061 |
| Dreaming or nightmares | 18.3% | 20.7% | 24.2% | .744 |
| Nausea | 8.7% | 6.3% | 6.1% | .783 |
| Headaches | 9.6% | 6.3% | 18.2% | .134 |
| Diarrhea | 0.0% | 2.7% | 3.0% | .228 |
| Skin Rash | 0.0% | 1.8% | 3.0% | .284 |
| Suicidal thinking or behavior | 1.0% | 0.9% | 0.0% | .999 |
| Dry Mouth | 16.4% | 11.7% | 12.1% | .592 |
| General muscle aches | 21.2% | 15.3% | 27.3% | .250 |
| Flushing or sweating | 28.9% | 19.8% | 33.3% | .172 |
| A change in how things taste | 13.5% | 6.3% | 3.0% | .102 |
| Confusion | 3.9% | 4.5% | 3.0% | .924 |
a
Respondents were asked to rate the severity of side effects they were experiencing in past 24 hours; response categories were 0 = none, 1 = slight, 2 = mild, 3 = moderate, and 4 = severe.
b
Mixed logistic regression models with data collection site entered as a random effect were estimated to test the statistical significance of intervention.