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. 2013 Nov 5;8(11):e79162. doi: 10.1371/journal.pone.0079162

Figure 5. The in vivo tumorgenesis assay and metastasis assay in nude mice.

Figure 5

Nude mice inoculated with SIRT1 si-RNA-transfected cells had markedly reduced tumor volume compared to mice received cells transfected with control si-RNA transfection (730±141vs. 1153±112, mm3 , P<0.001, Figure 5a and 5b).The in vivo metastasis assay shows the inoculation with SIRT1 si-RNA-transfected cells in nude mice had dramatically reduced numbers of metastatic tumors in lung tissues than control si-RNA-transfected cells (4.4±0.9 vs. 2.1±0.5, P<0.001, Figure 5c).