Table 3. Pooled measures for the association between the PAI-1 -675 4G/5G polymorphism and susceptibility to diabetic nephropathy.
| Comparisions | Data | n | Heterogeneity | OR (95% CI) | Model | p | |||
|---|---|---|---|---|---|---|---|---|---|
| Studies | Cases | Controls | I 2 (%) | P | |||||
| Allelic comparisions | Overall | 7 | 1060 | 1139 | 0 | 0.763 | 1.10(0.98-1.25) | REM | 0.103 |
| T1D | 4 | 466 | 451 | 0 | 0.425 | 1.16(0.97-1.40) | REM | 0.108 | |
| T2D | 3 | 594 | 688 | 0 | 0.831 | 1.06(0.91-1.25) | REM | 0.441 | |
| Dominant | Overall | 7 | 1060 | 1139 | 0 | 0.682 | 1.06(0.86-1.31) | REM | 0.566 |
| T1D | 4 | 466 | 451 | 0 | 0.598 | 0.94(0.68-1.30) | REM | 0.699 | |
| T2D | 3 | 594 | 688 | 0 | 0.577 | 1.16(0.88-1.53) | REM | 0.281 | |
| Recessive | Overall | 7 | 1060 | 1139 | 67.1 | 0.006 | 1.32(0.93-1.88) | REM | 0.114 |
| T1D | 4 | 466 | 451 | 71.9 | 0.014 | 1.72(0.94-3.16) | REM | 0.080 | |
| T2D | 3 | 594 | 688 | 45.6 | 0.159 | 1.04(0.74-1.46) | REM | 0.821 | |
| Co-dominant | Overall | 7 | 548 | 554 | 0 | 0.933 | 1.23(0.96-1.57) | REM | 0.107 |
| T1D | 4 | 253 | 200 | 0 | 0.721 | 1.34(0.90-1.98) | REM | 0.148 | |
| T2D | 3 | 295 | 354 | 0 | 0.898 | 1.16(0.84-1.60) | REM | 0.369 |
Note: Allelic comparisions, 4G vs. 5G; REM, Random effect model. T1D, type 1 diabetes; T2D, type 2 diabetes. Studies on T1D were all from Asian descent, and those on T2D were all from European descent.