Table 4. Pooled measures for the association between the PAI-1 -675 4G/5G polymorphism and susceptibility to diabetic retinopathy.
| Comparisions | Data | n | Heterogeneity | OR (95% CI) | Model | p | |||
|---|---|---|---|---|---|---|---|---|---|
| Studies | Cases | Controls | I 2 (%) | P | |||||
| Allelic comparisions | Overall | 10 | 1327 | 1557 | 10 | 0.350 | 1.09(0.97-1.22) | REM | 0.160 |
| Asian | 4 | 438 | 338 | 0 | 0.443 | 0.95(0.77-1.17) | REM | 0.624 | |
| European | 5 | 819 | 1117 | 0 | 0.653 | 1.12(0.98-1.28) | REM | 0.09 | |
| Dominant | Overall | 10 | 1327 | 1557 | 36.5 | 0.116 | 1.05(0.82-1.34) | REM | 0.695 |
| Asian | 4 | 438 | 338 | 6.7 | 0.360 | 0.94(0.63-1.41) | REM | 0.765 | |
| European | 5 | 819 | 1117 | 0 | 0.626 | 0.99(0.80-1.21) | REM | 0.910 | |
| Recessive | Overall | 10 | 1327 | 1557 | 22.8 | 0.233 | 1.18(0.96-1.46) | REM | 0.128 |
| Asian | 4 | 438 | 338 | 0 | 0.560 | 0.93(0.68-1.26) | REM | 0.629 | |
| European | 5 | 819 | 1117 | 18.7 | 0.295 | 1.38(1.07-1.79) | REM | 0.015 | |
| Co-dominant | Overall | 10 | 704 | 784 | 19.6 | 0.263 | 1.22(0.94-1.58) | REM | 0.132 |
| Asian | 4 | 226 | 172 | 0 | 0.413 | 0.94(0.61-1.46) | REM | 0.779 | |
| European | 5 | 452 | 555 | 8.4 | 0.359 | 1.31(0.98-1.75) | REM | 0.068 |
Note: Allelic comparisions, 4G vs. 5G; REM, Random effect model.