. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Ann Rheum Dis. 2013 Feb 26;72(12):10.1136/annrheumdis-2012-202742. doi: 10.1136/annrheumdis-2012-202742

Table 3.

Combined analysis of the allele frequencies of Xq28 genetic variants comparing limited cutaneous systemic sclerosis patients against diffuse cutaneous systemic sclerosis patients from Spain, USA, Germany, The Netherlands and UK

rs#	Gene	Subgroup (N)	MAF (%)	M-H Allele test

				p Value^*	OR (95% CI)^†
rs1059702	IRAK1	lcSSc (n=1969)	15.49
rs1059702	IRAK1	dcSSc (n=921)	18.08	0.022	1.19 (1.02 to 1.37)
rs17435	MECP2	lcSSc (n=2044)	20.79
rs17435	MECP2	dSSc (n=946)	23.36	0.026	1.16 (1.02 to 1.32)

All p values have been calculated for the allelic model.

^†

OR for the minor allele.

lcSSc, limited cutaneous systemic sclerosis; dcSSc, diffuse cutaneous systemic sclerosis; MAF, minor allele frequency; M-H, Mantel-Haenszel test under fixed effects; NA, not applicable.